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Download Large Animals as Models for Human Diseases PDF
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Publisher : Academic Press
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ISBN 10 : 9780323994422
Pages : 354 pages
Rating : 4.3/5 (239 users)
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Download or read book Large Animals as Models for Human Diseases written by Ya-Xiong Tao and published by Academic Press. This book was released on 2022-05-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Large Animals as Models for Human Diseases, Volume 189 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of important topics, including Sheep as a model for neuroendocrinology research, Relevance of dog as a model for urologic diseases, Relevance of lactocrine hypothesis to human maternal programming of development, Comparative aspects of embryo implantation, Pig as an animal model for obesity, Canine models of cancer, Bovine model for human ovarian diseases, Mutations in G protein-coupled receptors in large animals: Modeling human diseases, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Molecular Biology and Translational Science series Updated release includes the latest information on Large Animals as Models for Human Diseases

Download Animal Models for the Study of Human Disease PDF
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Publisher : Academic Press
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ISBN 10 : 9780128096994
Pages : 1198 pages
Rating : 4.1/5 (28 users)
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Download or read book Animal Models for the Study of Human Disease written by P. Michael Conn and published by Academic Press. This book was released on 2017-06-20 with total page 1198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

Download Animal Models for the Study of Human Disease PDF
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Publisher : Elsevier Inc. Chapters
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ISBN 10 : 9780128072004
Pages : 1108 pages
Rating : 4.1/5 (28 users)
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Download or read book Animal Models for the Study of Human Disease written by Lina Badimon and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental approaches to understand the pathophysiology of atherosclerosis and thrombosis involve the combination of both cellular and animal approaches. Animals have been instrumental in biomedical research in order to provide a better understanding on the mechanisms that have already been outlined in in vitro studies. Atherosclerosis studies were firstly carried out in rodents using diet-induced atherosclerosis approaches. However, these diets were un-physiological and the developed lesions were often limited in size, composition, and location largely differing from humans. During the last years, with the advent of molecular genetics and genetic manipulation techniques, the development of gene-engineered animals has allowed an explosion in the number of models resulting in a tremendous progress in the understanding of both atherosclerosis and thrombosis. However, direct translation from rodents to humans has to be taken with caution because of the well-reported species-related differences. Although there is no known animal model for human disease, large animal models have demonstrated better suitability for translation to humans. For instance swine, a species that spontaneously develops atherosclerosis and thrombosis, are more closely mimics of the macrovascular-related thrombotic complications found in humans. This book chapter provides an in depth overview of the currently available small and large animal modelsof atherosclerosis and thrombosis and examinestheir applicability for translational research purposes as well as highlights species-related differences with humans.

Download Large Animals as Models for Human Diseases PDF
Author :
Publisher : Elsevier
Release Date :
ISBN 10 : 9780323994415
Pages : 354 pages
Rating : 4.3/5 (239 users)
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Download or read book Large Animals as Models for Human Diseases written by Ya-Xiong Tao and published by Elsevier. This book was released on 2022-06-15 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Large Animals as Models for Human Diseases, Volume 189 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of important topics, including Sheep as a model for neuroendocrinology research, Relevance of dog as a model for urologic diseases, Relevance of lactocrine hypothesis to human maternal programming of development, Comparative aspects of embryo implantation, Pig as an animal model for obesity, Canine models of cancer, Bovine model for human ovarian diseases, Mutations in G protein-coupled receptors in large animals: Modeling human diseases, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Molecular Biology and Translational Science series Updated release includes the latest information on Large Animals as Models for Human Diseases

Download Animal Models for the Study of Human Disease PDF
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Publisher : Elsevier Inc. Chapters
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ISBN 10 : 9780128071984
Pages : 1108 pages
Rating : 4.1/5 (28 users)
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Download or read book Animal Models for the Study of Human Disease written by Li Chen and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: With advances in molecular and genomic research offering novel insights into cardiovascular diseases, many transgenic animal models have been recently developed and characterized. Currently, more than 90 percent of all laboratory animal experiments are conducted in mice and rats. Although there are many scientific advantages to using small animal models, it has been recently recognized that many exciting therapeutic targets identified in small animals are not validated in clinical trials in patients. Thus, suitable large animal models, particularly under conscious state with appropriate direct measurements of cardiovascular function, are needed to serve as a better translational bridge between preclinical and clinical studies. In this chapter, we primarily focus on surgically instrumented large animal models of common cardiovascular disease studied in the conscious state. In addition, several important physiological factors that influence the characteristics of the models, as well as the importance of proper data interpretation, will also be discussed.

Download Experimental Animal Models of Human Diseases PDF
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Publisher : BoD – Books on Demand
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ISBN 10 : 9781789231649
Pages : 408 pages
Rating : 4.7/5 (892 users)
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Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Download Animal Models for the Study of Human Disease PDF
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Publisher : Elsevier Inc. Chapters
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ISBN 10 : 9780128072226
Pages : 1108 pages
Rating : 4.1/5 (28 users)
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Download or read book Animal Models for the Study of Human Disease written by Bernhard Aigner and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established. In the recent years, genetically engineered pigs were increasingly generated as biomedical research tools for specific human genetic diseases. Here, we review the current state of the techniques used for the production of genetically engineered pigs as well as the establishment of genetically engineered pigs as models for human diseases.

Download Animal Models of Human Disease PDF
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ISBN 10 : WISC:89034682898
Pages : pages
Rating : 4.:/5 (89 users)
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Download or read book Animal Models of Human Disease written by and published by . This book was released on 1973 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Spontaneous Animal Models of Human Disease PDF
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Publisher : Elsevier
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ISBN 10 : 9780323138284
Pages : 324 pages
Rating : 4.3/5 (231 users)
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Download or read book Spontaneous Animal Models of Human Disease written by Edwin J. Andrews and published by Elsevier. This book was released on 2012-12-02 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models. The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.

Download Animal Models of Human Disease PDF
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Publisher : Academic Press
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ISBN 10 : 9780123848796
Pages : 550 pages
Rating : 4.1/5 (238 users)
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Download or read book Animal Models of Human Disease written by and published by Academic Press. This book was released on 2011-03-04 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Download Animal Models in Cancer Research and Human Disease PDF
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Publisher : Nova Biomedical Books
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ISBN 10 : 1624175880
Pages : 162 pages
Rating : 4.1/5 (758 users)
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Download or read book Animal Models in Cancer Research and Human Disease written by Sean A. Murray and published by Nova Biomedical Books. This book was released on 2014-05-14 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the applications, outcomes and controversies of using animal models in cancer research and human disease. Topics include murine models of sporadic and inflammation-related colon carcinogenesis with particular focus on the AOM/DSS chemically induced colorectal cancer model; large animal models of human cardiovascular disease; developments of cell therapeutic strategies for Alzheimer's disease using animal models; the techniques and limitations of murine models of human colorectal cancer; animal models for antineoplastic chemotherapy-induced alopecia; and development of columnar-lined esophagus with or without goblet cells in rate duodengastroesophageal reflux models through gut regenerative cell lineage (GRCL).

Download Acta P    diatrica PDF
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ISBN 10 : UCLA:L0098921208
Pages : 344 pages
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Download or read book Acta P diatrica written by and published by . This book was released on 2007 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Animal Models in Cancer Research and Human Disease PDF
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Publisher : Nova Science Pub Incorporated
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ISBN 10 : 1624175872
Pages : 135 pages
Rating : 4.1/5 (758 users)
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Download or read book Animal Models in Cancer Research and Human Disease written by Sean A. Murray and published by Nova Science Pub Incorporated. This book was released on 2013-01-01 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the applications, outcomes and controversies of using animal models in cancer research and human disease. Topics include murine models of sporadic and inflammation-related colon carcinogenesis with particular focus on the AOM/DSS chemically induced colorectal cancer model; large animal models of human cardiovascular disease; developments of cell therapeutic strategies for Alzheimer's disease using animal models; the techniques and limitations of murine models of human colorectal cancer; animal models for antineoplastic chemotherapy-induced alopecia; and development of columnar-lined oesophagus with or without goblet cells in rate duodengastroesophageal reflux models through gut regenerative cell lineage (GRCL).

Download Animal Models for the Study of Human Disease PDF
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Publisher : Elsevier Inc. Chapters
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ISBN 10 : 9780128072080
Pages : 1108 pages
Rating : 4.1/5 (28 users)
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Download or read book Animal Models for the Study of Human Disease written by Joshua G. Hunter and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteomyelitis, or an infection of the bone, remains a major orthopaedic problem without a solution. As these unmet needs stem from our limited knowledge of microbial pathogenesis of chronic osteomyelitis, and the host response required for protective immunity, animal models of bone infection are still being developed after more than a century of research. Moreover, since osteomyelitis research spans the fields of microbiology, immunology, bone biology, biomechanics, orthopaedics and pre-clinical testing of drugs, vaccines and implants, the animal models used for this research must be equally diverse in their size and sophistication. Thus, the goals of this Chapter are to review the clinical problems and the animal models that have been developed to elucidate the etiology of osteomyelitis and evaluate potential interventions. Finally, since bone infections in which biofilm bacteria have colonized the calcified tissue are by definition incurable, we will discuss current biomarker research aimed at understanding in vivo bacterial growth and bone adaptation during chronic osteomyelitis using bioluminescent imaging and micro-computed tomography (μCT) outcome measures, respectively.

Download Animal Biotechnology 2 PDF
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Publisher : Springer
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ISBN 10 : 9783319923482
Pages : 303 pages
Rating : 4.3/5 (199 users)
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Download or read book Animal Biotechnology 2 written by Heiner Niemann and published by Springer. This book was released on 2018-08-01 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume textbook provides a comprehensive overview on the broad field of Animal Biotechnology with a special focus on livestock reproduction and breeding. The reader will be introduced to a variety of state-of-the-art technologies and emerging genetic tools and their applications in animal production. Also, ethics and legal aspects of animal biotechnology will be discussed and new trends and developments in the field will be critically assessed. The two-volume work is a must-have for graduate students, advanced undergraduates and researchers in the field of veterinary medicine, genetics and animal biotechnology. This second volume is dedicated to genetic tools in animal biotechnology such as somatic cloning, transgenic technologies and the application of stem cells in livestock breeding. Also, ethics and legal aspects are discussed.

Download Animal Models for the Study of Human Disease PDF
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Publisher : Elsevier Inc. Chapters
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ISBN 10 : 9780128071977
Pages : 1108 pages
Rating : 4.1/5 (28 users)
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Download or read book Animal Models for the Study of Human Disease written by Ross A. Breckenridge and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial disease is one of the largest medical burdens facing populations of the developed world. Increasing diabetes and obesity in both the developed and developing world suggests that this problem will increase with time. So far, development of novel therapeutic approaches to myocardial disease has lagged behind medical need. One of the key components lacking from this area of medicine is reliable animal systems to model increasingly complex patient populations. This chapter takes a disease-centred approach to reviewing commonly used animal models of myocardial disease. It goes on to discuss possible future approaches to adapting existing models to the changing spectrum of cardiac disease.

Download Animal Models for the Study of Human Disease PDF
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Publisher : Elsevier Inc. Chapters
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ISBN 10 : 9780128072073
Pages : 1108 pages
Rating : 4.1/5 (28 users)
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Download or read book Animal Models for the Study of Human Disease written by Meghan E. McGee-Lawrence and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skeleton is a multifunctional organ system that serves several vital roles in the body. Although bone has the ability to remodel itself to repair damage and respond to calcium demands, it is subject to the rigors of aging, hormonal changes, and environment. Understanding the mechanisms that cause bone loss is an important facet of human medicine. Animal models permit mechanistic study of processes that regulate development and maintenance of skeletal mass, enabling meticulous investigation of new orthopedic strategies or bone-targeted pharmacologic therapies. The selection of an appropriate animal model, choice of skeletal analysis techniques, and proper interpretation of data are vital components of experimental design and analysis in bone research. In this chapter, we review time-tested criteria for choosing appropriate animal models, describe several common animal models of osteoporosis, and summarize some of the basic methodology available for in vivo, ex vivo and in vitro analysis of skeletal biology.