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Download Handbook of Targeted Delivery of Imaging Agents PDF
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Publisher : CRC Press
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ISBN 10 : 0849383080
Pages : 762 pages
Rating : 4.3/5 (83 users)
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Download or read book Handbook of Targeted Delivery of Imaging Agents written by Vladimir P. Torchilin and published by CRC Press. This book was released on 1995-08-23 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.

Download Targeted Killings PDF
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Publisher : OUP Oxford
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ISBN 10 : 9780191625909
Pages : 520 pages
Rating : 4.1/5 (916 users)
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Download or read book Targeted Killings written by Claire Finkelstein and published by OUP Oxford. This book was released on 2012-03-01 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: The war on terror is remaking conventional warfare. The protracted battle against a non-state organization, the demise of the confinement of hostilities to an identifiable battlefield, the extensive involvement of civilian combatants, and the development of new and more precise military technologies have all conspired to require a rethinking of the law and morality of war. Just war theory, as traditionally articulated, seems ill-suited to justify many of the practices of the war on terror. The raid against Osama Bin Laden's Pakistani compound was the highest profile example of this strategy, but the issues raised by this technique cast a far broader net: every week the U.S. military and CIA launch remotely piloted drones to track suspected terrorists in hopes of launching a missile strike against them. In addition to the public condemnation that these attacks have generated in some countries, the legal and moral basis for the use of this technique is problematic. Is the U.S. government correct that nations attacked by terrorists have the right to respond in self-defense by targeting specific terrorists for summary killing? Is there a limit to who can legitimately be placed on the list? There is also widespread disagreement about whether suspected terrorists should be considered combatants subject to the risk of lawful killing under the laws of war or civilians protected by international humanitarian law. Complicating the moral and legal calculus is the fact that innocent bystanders are often killed or injured in these attacks. This book addresses these issues. Featuring chapters by an unrivalled set of experts, it discusses all aspects of targeted killing, making it unmissable reading for anyone interested in the implications of this practice.

Download Targeted Killing PDF
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Publisher : Cambridge University Press
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ISBN 10 : 9781316552841
Pages : pages
Rating : 4.3/5 (165 users)
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Download or read book Targeted Killing written by Markus Gunneflo and published by Cambridge University Press. This book was released on 2016-05-12 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Looking beyond the events of the second intifada and 9/11, this book reveals how targeted killing is intimately embedded in both Israeli and US statecraft, and in the problematic relationship between sovereign authority and lawful violence underpinning the modern state system. It details the legal and political issues raised in targeted killing as it has emerged in practice, including questions of domestic constitutional authority, the use of force in international law, the law of belligerent occupation, the law of targeting and human rights law. The distinctive nature of Israeli and US targeted killing is analysed in terms of the compulsion of legality characteristic of the liberal constitutional state, a compulsion that demands the ability to distinguish between legal 'targeted killing' and extra-legal 'political assassination'. The effect is a highly legalized framework for the extraterritorial killing of designated terrorists that may significantly affect the international law of force.

Download Targeted Jobs Tax Credit PDF
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ISBN 10 : UIUC:30112033965242
Pages : 34 pages
Rating : 4.:/5 (31 users)
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Download or read book Targeted Jobs Tax Credit written by United States. General Accounting Office and published by . This book was released on 1991 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Targeted Violence PDF
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Publisher : CRC Press
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ISBN 10 : 9781439825136
Pages : 331 pages
Rating : 4.4/5 (398 users)
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Download or read book Targeted Violence written by Glenn P. McGovern and published by CRC Press. This book was released on 2010-04-05 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawn from case examples of incidents from around the world, Targeted Violence: A Statistical and Tactical Analysis of Assassinations, Contract Killings, and Kidnappings is the most complete resource of information on the attack methodologies, tactics used, and groups responsible for targeted killings and kidnappings. The author, a former SWAT and

Download Drones and the Ethics of Targeted Killing PDF
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Publisher : Rowman & Littlefield
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ISBN 10 : 9781442231573
Pages : 212 pages
Rating : 4.4/5 (422 users)
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Download or read book Drones and the Ethics of Targeted Killing written by Kenneth R. Himes and published by Rowman & Littlefield. This book was released on 2015-09-03 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drones have become an essential part of U.S. national security strategy, but most Americans know little about how they are used, and we receive conflicting reports about their outcomes. In Drones and the Ethics of Targeted Killing, ethicist Kenneth R. Himes provides not only an overview of the role of drones in national security but also an important exploration of the ethical implications of drone warfare—from the impact on terrorist organizations and civilians to how piloting drones shapes soldiers. Targeted killings have played a role in politics from ancient times through today, so the ethical challenges around how to protect against threats are not new. Himes leads readers through the ethics of targeted killings in history from ancient times to the contemporary Israeli-Palestinian conflict, then looks specifically at the new issues raised through the use of drones. This book is a powerful look at a pressing topic today.

Download Targeted Molecular Imaging PDF
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Publisher : Taylor & Francis
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ISBN 10 : 9781439841969
Pages : 388 pages
Rating : 4.4/5 (398 users)
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Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by Taylor & Francis. This book was released on 2012-02-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Download Debating Targeted Killing PDF
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Publisher : Oxford University Press
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ISBN 10 : 9780190906931
Pages : 288 pages
Rating : 4.1/5 (99 users)
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Download or read book Debating Targeted Killing written by Tamar Meisels and published by Oxford University Press. This book was released on 2020-05-14 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known terrorists are often targeted for death by the governments of Israel and the United States. Several thousand have been killed by drones or by operatives on the ground in the last twenty years. Is this form of killing justified, when hundreds or thousands of lives are possibly at risk at the hands of a known terrorist? Is there anything about it that should disturb us? Ethically-sound and practical answers to these questions are more difficult to come by than it might seem. Renowned political theorists Jeremy Waldron and Tamar Meisels here defend two competing positions on the legitimacy of targeted killing as used in counterterrorism strategy in this riveting and essential for-and-against book. The volume begins with a joint introduction, briefly setting out the terms of discussion, and presenting a short historical overview of the practice: what targeted killing is, and how it has been used in which conflicts and by whom. It then hones in on killings themselves and the element of targeting. The authors tackle difficult and infinitely complex subjects, for example the similarities and differences between targeted killing of terrorists and ordinary killings in combat, and they ask whether targeted killing can be regarded as a law enforcement strategy, or as a hybrid between combat and law enforcement. They compare the practice of targeted killing with assassination and the use of death squads. And they consider the likelihood that targeted killing has been or will be abused against insurgents, criminals, or political opponents. Meisels analyzes the assassination by Israeli operatives of nuclear scientists working for regimes hostile to Israel. Meisels and Waldron carefully consider whether this sort of killing can ever be justified in terms of the danger it, in theory, averts. The conclusions drawn are at once as surprising as they are insightful, cautioning us against a world in which targeted killing is the norm as it proliferates rapidly. This is essential reading not only for students of political and war theory and military personnel, but for anyone interested in or concerned by the future of targeted killing.

Download Targeted Drug Strategies for Cancer and Inflammation PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9781441984173
Pages : 254 pages
Rating : 4.4/5 (419 users)
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Download or read book Targeted Drug Strategies for Cancer and Inflammation written by Ann L. Jackman and published by Springer Science & Business Media. This book was released on 2011-05-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.

Download Targeted  Mills   Boon Intrigue   The Blade Brothers of Cougar County  Book 1  PDF
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Publisher : HarperCollins UK
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ISBN 10 : 9781472034724
Pages : 224 pages
Rating : 4.4/5 (72 users)
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Download or read book Targeted Mills Boon Intrigue The Blade Brothers of Cougar County Book 1 written by Lori L. Harris and published by HarperCollins UK. This book was released on 2014-01-27 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: ZEROING IN Months after his wife had been brutally murdered, FBI profiler Alec Blade was on the desperate hunt to bring her murderer to justice. But after setting up residence in a sleepy Florida town, Alec made a startling discovery: The killer had a new target.

Download Targeted Muscle Reinnervation PDF
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Publisher : Taylor & Francis
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ISBN 10 : 9781439860816
Pages : 225 pages
Rating : 4.4/5 (398 users)
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Download or read book Targeted Muscle Reinnervation written by Todd A. Kuiken and published by Taylor & Francis. This book was released on 2013-07-23 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implement TMR with Your Patients and Improve Their Quality of Life Developed by Dr. Todd A. Kuiken and Dr. Gregory A. Dumanian, targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantages over other neural-machine interfaces for the improved control of artificial limbs. Targeted Muscle Reinnervation: A Neural Interface for Artificial Limbs provides a template for the clinical implementation of TMR and a resource for further research in this new area of science. After describing the basic scientific concepts and key principles underlying TMR, the book presents surgical approaches to transhumeral and shoulder disarticulation amputations. It explores the possible role of TMR in the prevention and treatment of end-neuromas and details the principles of rehabilitation, prosthetic fitting, and occupational therapy for TMR patients. The book also describes transfer sensation and discusses the surgical and functional outcomes of the first several TMR patients. It concludes with emerging research on using TMR to further improve the function and quality of life for people with limb loss. With contributions from renowned leaders in the field, including Drs. Kuiken and Dumanian, this book is a useful guide to implementing TMR in patients with high-level upper limb amputations. It also supplies the foundation to enable improvements in TMR techniques and advances in prosthetic technology.

Download Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors PDF
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Publisher : Academic Press
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ISBN 10 : 9780128122495
Pages : 478 pages
Rating : 4.1/5 (281 users)
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Download or read book Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors written by Prashant Kesharwani and published by Academic Press. This book was released on 2018-04-20 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Download Advances in Targeted Cancer Therapy PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9783764374143
Pages : 303 pages
Rating : 4.7/5 (643 users)
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Download or read book Advances in Targeted Cancer Therapy written by Richard M. Schultz and published by Springer Science & Business Media. This book was released on 2006-01-24 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.

Download Targeted Jobs Tax Credit PDF
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Publisher :
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ISBN 10 : STANFORD:36105009876801
Pages : 334 pages
Rating : 4.F/5 ( users)
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Download or read book Targeted Jobs Tax Credit written by United States. Congress. Senate. Committee on Finance. Subcommittee on Economic Growth, Employment, and Revenue Sharing and published by . This book was released on 1981 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Targeted For Murder  Mills   Boon Love Inspired Suspense   Wilderness  Inc   Book 1  PDF
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Publisher : HarperCollins UK
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ISBN 10 : 9781474058681
Pages : 224 pages
Rating : 4.4/5 (74 users)
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Download or read book Targeted For Murder Mills Boon Love Inspired Suspense Wilderness Inc Book 1 written by Elizabeth Goddard and published by HarperCollins UK. This book was released on 2016-10-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: MOUNTAIN PURSUIT

Download Carbon Nanotubes for Targeted Drug Delivery PDF
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Publisher : Springer Nature
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ISBN 10 : 9789811509100
Pages : 106 pages
Rating : 4.8/5 (115 users)
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Download or read book Carbon Nanotubes for Targeted Drug Delivery written by Md Saquib Hasnain and published by Springer Nature. This book was released on 2019-11-08 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed introduction to carbon nanotubes (CNTs) for targeted drug delivery. After a brief overview of the classification, preparation, and characterization of carbon nanotubes, it focuses on their use in targeted drug delivery. It presents CNTs for brain targeting, ocular targeting, cancer targeting, and lymphatic targeting, as well as antibody therapy. The book also includes chapters on carbon nanotubes for controlled drug delivery, transdermal drug delivery, solubility enhancement, vaccine delivery, gene delivery, and as quantum dots. Last but not least, it addresses the absorption and transportation of CNTs, toxicity and regulatory considerations, as well as clinical trials and the market status of CNTs. The book offers a comprehensive, self-contained reference guide, with all topics covered concisely and with the help of figures, tables and flowcharts.

Download Targeted Immunotherapy for Cancer PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889760749
Pages : pages
Rating : 4.8/5 (897 users)
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Download or read book Targeted Immunotherapy for Cancer written by William Valentine Williams and published by Frontiers Media SA. This book was released on 2022-05-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor, William Williams, is the president and CEO of BriaCell, which is developing a targeted immunotherapy for breast cancer. This includes raising money to support research and clinical programs and applying for grants. All other Topic Editors declare no competing interests with regards to the Research Topic subject.