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Download Advances in Targeted Cancer Therapy PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9783764374143
Pages : 303 pages
Rating : 4.7/5 (643 users)
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Download or read book Advances in Targeted Cancer Therapy written by Richard M. Schultz and published by Springer Science & Business Media. This book was released on 2006-01-24 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.

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ISBN 10 : 1618962744
Pages : pages
Rating : 4.9/5 (627 users)
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Download or read book Advances in Targeted Cancer Therapy written by Rui-hua Xu and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Advances in Cancer Treatment PDF
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Publisher : Springer Nature
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ISBN 10 : 9783030683344
Pages : 109 pages
Rating : 4.0/5 (36 users)
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Download or read book Advances in Cancer Treatment written by Iago Dillion Lima Cavalcanti and published by Springer Nature. This book was released on 2021-02-24 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers the pathophysiology of cancer, exploring the difficulty of optimal treatment due to the complexity and diversity of cancer types. The search for distinctive molecular biology characteristics of tumor cells is especially relevant in the identification of overexpressed receptors and proteins that can be used as a target for cancer treatment. We highlight the main therapeutic modalities, particularly conventional systemic chemotherapy, addressing its mechanisms of action, therapeutic classes and even the toxic effects. We also describe the main tumor markers, their importance in the diagnosis and treatment of cancer, and the specificity of tumor cells. The first chapters serve as an introduction to the central topic of this book, targeted therapy. Key aspects of target therapy, such as classes of drugs, immunotherapy, monoclonal antibodies, checkpoint inhibitors, cancer vaccines and tyrosine kinase inhibitors are presented, and, for each one, the benefits, as well as the adverse effects are reported. Chapter 6 compares conventional systemic chemotherapy and targeted therapy, identifies the risks and benefits and also the eligibility criteria for patient care. The possibility of targeted therapy replacing conventional chemotherapy is discussed while reviewing studies that demonstrate the benefits of combining both types of treatment. Finally, the introduction of pharmaceutical nanotechnology to improve antineoplastic agents is addressed in the last chapter and sets the direction for future research in cancer treatment. This is a valuable resource for many health professionals including physicians, pharmacists, nurses, researchers and students interested in the field of oncology.

Download Advances of Targeted Therapy in Gynecologic Malignancies PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889760268
Pages : pages
Rating : 4.8/5 (897 users)
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Download or read book Advances of Targeted Therapy in Gynecologic Malignancies written by Haifeng Qiu and published by Frontiers Media SA. This book was released on 2022-04-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Successes and Limitations of Targeted Cancer Therapy PDF
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Publisher : Karger Medical and Scientific Publishers
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ISBN 10 : 9783318025422
Pages : 124 pages
Rating : 4.3/5 (18 users)
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Download or read book Successes and Limitations of Targeted Cancer Therapy written by S. Peters and published by Karger Medical and Scientific Publishers. This book was released on 2014-02-19 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.

Download Targeted Cancer Therapy PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9781603274241
Pages : 446 pages
Rating : 4.6/5 (32 users)
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Download or read book Targeted Cancer Therapy written by Razelle Kurzrock and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.

Download Therapeutic Progress in Oncology PDF
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Publisher : John Wiley & Sons
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ISBN 10 : 9781786304933
Pages : 202 pages
Rating : 4.7/5 (863 users)
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Download or read book Therapeutic Progress in Oncology written by Jacques Barbet and published by John Wiley & Sons. This book was released on 2020-03-17 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combined effects of population growth and aging have led to an increase in the number of cancers. Preventing, diagnosing, treating and curing cancer are therefore, more than ever, imperatives facing medicine – especially to continue the decrease in cancers mortality rates and to improve the quality of survival. Over time, the classic modes of treatment (surgery, external beam radiotherapy, chemotherapy) have become more refined and efficient. From the beginning of this century, new therapeutic options have been developed: targeted cancer therapy, targeted radionuclide therapy and immunologic therapies based on monoclonal antibodies, cellular therapy and vaccinations. Artificial intelligence and machine learning are also being introduced to the field of oncology. Starting with the basic scientific principles relevant to oncology, this book explains and makes these concepts and innovations accessible to a wide audience – especially in the interest of patients. It also contributes to the oncological field of 4P medicine – with 4P standing for predictive, preventive, personalized and participative.

Download Venom and Toxin as Targeted Therapy PDF
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Publisher : MDPI
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ISBN 10 : 9783039211890
Pages : 178 pages
Rating : 4.0/5 (392 users)
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Download or read book Venom and Toxin as Targeted Therapy written by Hang Fai (Henry) Kwok and published by MDPI. This book was released on 2019-10-01 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Download Handbook of Research on Advancements in Cancer Therapeutics PDF
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Publisher : IGI Global
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ISBN 10 : 9781799865315
Pages : 913 pages
Rating : 4.7/5 (998 users)
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Download or read book Handbook of Research on Advancements in Cancer Therapeutics written by Kumar, Sumit and published by IGI Global. This book was released on 2020-11-27 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.

Download Small Molecules in Oncology PDF
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Publisher : Springer Science & Business
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ISBN 10 : 9783642544903
Pages : 417 pages
Rating : 4.6/5 (425 users)
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Download or read book Small Molecules in Oncology written by Uwe M. Martens and published by Springer Science & Business. This book was released on 2014-04-22 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Download Advances in Targeted Therapy for Metastatic Colorectal Cancer PDF
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ISBN 10 : OCLC:1074447918
Pages : 16 pages
Rating : 4.:/5 (17 users)
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Download or read book Advances in Targeted Therapy for Metastatic Colorectal Cancer written by and published by . This book was released on 2006 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Targeted Cancer Treatment in Silico PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9781461483014
Pages : 227 pages
Rating : 4.4/5 (614 users)
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Download or read book Targeted Cancer Treatment in Silico written by Natalia L. Komarova and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Download Current Challenges in Personalized Cancer Medicine PDF
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Publisher : Academic Press
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ISBN 10 : 9780123984838
Pages : 576 pages
Rating : 4.1/5 (239 users)
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Download or read book Current Challenges in Personalized Cancer Medicine written by and published by Academic Press. This book was released on 2012-12-31 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease. Brought together some of the foremost basic science and clinical researchers Part of the renowned Advances in Pharmacology Serial Discussion of some of the new frontiers in the development of targeted cancer therapy

Download Small Molecules in Hematology PDF
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Publisher : Springer
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ISBN 10 : 9783319914398
Pages : 294 pages
Rating : 4.3/5 (199 users)
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Download or read book Small Molecules in Hematology written by Uwe M. Martens and published by Springer. This book was released on 2018-08-01 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.

Download New Nanomaterials and Techniques for Tumor targeted Systems PDF
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Publisher : Springer Nature
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ISBN 10 : 9789811551598
Pages : 463 pages
Rating : 4.8/5 (115 users)
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Download or read book New Nanomaterials and Techniques for Tumor targeted Systems written by Rongqin Huang and published by Springer Nature. This book was released on 2020-09-28 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.

Download Targeted Therapies for Solid Tumors PDF
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Publisher : Humana Press
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ISBN 10 : 9781493920471
Pages : 269 pages
Rating : 4.4/5 (939 users)
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Download or read book Targeted Therapies for Solid Tumors written by Antonio Russo and published by Humana Press. This book was released on 2015-03-11 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Download Targeted Therapies in Lung Cancer  Management Strategies for Nurses and Practitioners PDF
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Publisher : Springer
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ISBN 10 : 9783030165505
Pages : 120 pages
Rating : 4.0/5 (31 users)
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Download or read book Targeted Therapies in Lung Cancer Management Strategies for Nurses and Practitioners written by Marianne Davies and published by Springer. This book was released on 2019-07-16 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.