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Download Targeted Drug Strategies for Cancer and Inflammation PDF
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Publisher : Springer
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ISBN 10 : 144198416X
Pages : 254 pages
Rating : 4.9/5 (841 users)
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Download or read book Targeted Drug Strategies for Cancer and Inflammation written by Ann L. Jackman and published by Springer. This book was released on 2011-05-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.

Download Targeted Drug Strategies for Cancer and Inflammation PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9781441984173
Pages : 254 pages
Rating : 4.4/5 (419 users)
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Download or read book Targeted Drug Strategies for Cancer and Inflammation written by Ann L. Jackman and published by Springer Science & Business Media. This book was released on 2011-05-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.

Download Inflammation and Cancer PDF
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Publisher : Humana Press
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ISBN 10 : 1617379050
Pages : 408 pages
Rating : 4.3/5 (79 users)
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Download or read book Inflammation and Cancer written by Serguei V. Kozlov and published by Humana Press. This book was released on 2010-11-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.

Download Targeted Drug Delivery   Concepts and Design PDF
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Publisher : Springer
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ISBN 10 : 9783319113555
Pages : 790 pages
Rating : 4.3/5 (191 users)
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Download or read book Targeted Drug Delivery Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Download Inflammation and Gastrointestinal Cancers PDF
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Publisher : Springer
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ISBN 10 : 3642035027
Pages : 202 pages
Rating : 4.0/5 (35 users)
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Download or read book Inflammation and Gastrointestinal Cancers written by Janusz A. Z. Jankowski and published by Springer. This book was released on 2011-08-08 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in gastrointestinal mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it has fundamental clinical consequences, the principal of which is premalignant metaplasia throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for GI cancer. This book discusses all aspects of the relation between inflammation and GI cancer, from the basic science through to the translational science which is helping in the optimization of clinical management strategies. Among the topics considered are the impact of inherited syndromes; the roles of acid reflux, H. pylori, inflammatory bowel disease, and primary sclerosing cholangitis; screening strategies; targeted drug therapies; genetics; and the use of endoscopic methods. The authors are the best in their field, and this book is designed for the enthusiastic student as well as the professional in GI science and medicine.

Download Smart Coatings PDF
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Publisher : CRC Press
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ISBN 10 : 9781000646207
Pages : 106 pages
Rating : 4.0/5 (6 users)
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Download or read book Smart Coatings written by Vaibhav Sanjay Kathavate and published by CRC Press. This book was released on 2022-09-02 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on fundamentals, technology, synthesis, and characterizations and applied techniques from a practical point of view of coatings. The first three chapters offer a rigorous review of the application of these coatings to corrosion protection in various aerospace and oil and gas industries, and the subsequent chapters present a quick critical review of the state-of-the-art protection techniques of these coatings to novel biomedical applications such as clinical translations and tissue-engineered materials. Environmental, ergonomics, and aesthetic aspects and future perspectives are also explained at the end. Features: Explores the synthesis and application techniques of novel smart coatings in various research areas Presents a concise, critical, and state-of-the-art review of existing research on various types of smart coatings Ascertains the different mechanisms associated with the stimuli response of smart coatings Includes an exclusive chapter on real-time applications in the biomedical field Covers self-healing, self-cleaning, pH balance, early corrosion detection, and triggering mechanisms This book is aimed at researchers and graduate students specifically in smart coatings and thin films and corrosion, including chemical, materials science engineering, industrial and manufacturing engineering, and nanotechnology.

Download Biomaterials and Immune Response PDF
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Publisher : CRC Press
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ISBN 10 : 9781351377560
Pages : 249 pages
Rating : 4.3/5 (513 users)
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Download or read book Biomaterials and Immune Response written by Nihal Engin Vrana and published by CRC Press. This book was released on 2018-07-20 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Download Targeted Delivery of Small and Macromolecular Drugs PDF
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Publisher : CRC Press
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ISBN 10 : 9781420087734
Pages : 630 pages
Rating : 4.4/5 (2 users)
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Download or read book Targeted Delivery of Small and Macromolecular Drugs written by Ajit S. Narang and published by CRC Press. This book was released on 2010-05-12 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local rou

Download Targeting Human Inflammatory Skin Diseases With Natural Products  Exploring Potential Mechanisms and Regulatory Pathways PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889719938
Pages : 157 pages
Rating : 4.8/5 (897 users)
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Download or read book Targeting Human Inflammatory Skin Diseases With Natural Products Exploring Potential Mechanisms and Regulatory Pathways written by Bey Hing Goh and published by Frontiers Media SA. This book was released on 2022-01-07 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Comprehensive Supramolecular Chemistry II PDF
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Publisher : Elsevier
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ISBN 10 : 9780128031995
Pages : 4568 pages
Rating : 4.1/5 (28 users)
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Download or read book Comprehensive Supramolecular Chemistry II written by George W. Gokel and published by Elsevier. This book was released on 2017-06-22 with total page 4568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Supramolecular Chemistry II, Second Edition is a ‘one-stop shop’ that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996

Download Medicinal Chemistry of Anticancer Drugs PDF
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Publisher : Elsevier
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ISBN 10 : 9780444626677
Pages : 768 pages
Rating : 4.4/5 (446 users)
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Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendano and published by Elsevier. This book was released on 2015-06-11 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Download Cumulated Index Medicus PDF
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ISBN 10 : OSU:32436011073168
Pages : 1156 pages
Rating : 4.3/5 (243 users)
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Download or read book Cumulated Index Medicus written by and published by . This book was released on 1986 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Inflammation  Aging and Cancer PDF
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Publisher : Springer
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ISBN 10 : 9783319664750
Pages : 389 pages
Rating : 4.3/5 (196 users)
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Download or read book Inflammation Aging and Cancer written by Mahin Khatami and published by Springer. This book was released on 2018-01-17 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.

Download Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems PDF
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Publisher : Academic Press
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ISBN 10 : 9780128208885
Pages : 616 pages
Rating : 4.1/5 (282 users)
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Download or read book Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems written by Kamal Dua and published by Academic Press. This book was released on 2020-08-04 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Download Inflammation and Lung Cancer PDF
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Publisher : Springer
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ISBN 10 : 9781493927241
Pages : 212 pages
Rating : 4.4/5 (939 users)
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Download or read book Inflammation and Lung Cancer written by Steven M. Dubinett and published by Springer. This book was released on 2015-06-24 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there have been various discoveries connecting inflammation and lung cancer and clearly there is growing interest in this area of cancer research. The link between unresolved inflammation and cancer has been well established with estimates that 15% of cancer deaths are inflammation‐related. Evidence for this link includes the following: a) some inflammatory diseases are associated with increased risk of cancer development; b) inflammatory mediators are present surrounding and within most tumors; c) overexpression of inflammatory cytokines increases cancer development and progression in murine studies; d) inhibition of inflammatory mediators decreases cancer development and progression; and e) the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) has been found to decrease cancer incidence and delay progression. The volume will present aspects of the inflammatory tumor microenvironment (TME), its many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of micro‐RNAs (miRNAs) and an increase in a stem cell phenotype. The book will also cover the mechanisms of inflammatory mediators. Chronic overexpression of inflammatory mediators in the TME, as seen in smokers and patients with non‐small cell lung cancer (NSCLC), can also lead to increased tumor initiation, progression, invasion and metastasis. The volume will provide a comprehensive perspective of the latest findings and summaries of progress made regarding inflammation and its connection to lung cancer.

Download Colon Cancer Diagnosis and Therapy Vol  3 PDF
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Publisher : Springer Nature
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ISBN 10 : 9783030727024
Pages : 459 pages
Rating : 4.0/5 (37 users)
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Download or read book Colon Cancer Diagnosis and Therapy Vol 3 written by Dhananjay Shukla and published by Springer Nature. This book was released on 2022 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the third of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Download Nano Biomaterials for the Delivery of Therapeutic and Biological Cues for Regenerative Medicine PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889744459
Pages : 186 pages
Rating : 4.8/5 (897 users)
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Download or read book Nano Biomaterials for the Delivery of Therapeutic and Biological Cues for Regenerative Medicine written by Silvia Minardi and published by Frontiers Media SA. This book was released on 2022-02-21 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: