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Download Creation of Novel Targeted Antimicrobial Peptides PDF
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ISBN 10 : UCLA:L0096928718
Pages : 352 pages
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Download or read book Creation of Novel Targeted Antimicrobial Peptides written by Randal Hojem Eckert and published by . This book was released on 2006 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Quorum Sensing vs Quorum Quenching  A Battle with No End in Sight PDF
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Publisher : Springer
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ISBN 10 : 9788132219828
Pages : 391 pages
Rating : 4.1/5 (322 users)
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Download or read book Quorum Sensing vs Quorum Quenching A Battle with No End in Sight written by Vipin Chandra Kalia and published by Springer. This book was released on 2014-09-29 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

Download Antibiotics PDF
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Publisher : John Wiley & Sons
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ISBN 10 : 9783527659708
Pages : 576 pages
Rating : 4.5/5 (276 users)
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Download or read book Antibiotics written by Claudio O. Gualerzi and published by John Wiley & Sons. This book was released on 2013-09-05 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Download The Development and Utilization of Novel Antibiotic Alternatives PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782832502051
Pages : 189 pages
Rating : 4.8/5 (325 users)
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Download or read book The Development and Utilization of Novel Antibiotic Alternatives written by Wang Jiajun and published by Frontiers Media SA. This book was released on 2022-10-07 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Development of Novel Antimicrobial Agents PDF
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Publisher : Garland Science
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ISBN 10 : 1898486239
Pages : 284 pages
Rating : 4.4/5 (862 users)
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Download or read book Development of Novel Antimicrobial Agents written by Karl Lohner and published by Garland Science. This book was released on 2001-01-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents current research on the development of new classes of antibiotics with novel mechanisms of action. Leading international researchers from academia and industry present this unique collection of highly acclaimed reviews covering every aspect of this important topic. The authors also discuss strategies for the containment of antimicrobial resistance, and advocate a more sophisticated and prudent use of antibiotics.

Download Dental Caries PDF
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Publisher : Springer
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ISBN 10 : 9783662474501
Pages : 183 pages
Rating : 4.6/5 (624 users)
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Download or read book Dental Caries written by Zhou Xuedong and published by Springer. This book was released on 2015-10-20 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a well-illustrated and comprehensive guide to the etiology, clinical manifestations, diagnosis, clinical management and prevention of dental caries. Current challenging problems in the field are analyzed and the latest research findings, presented. After an introductory chapter on tooth development, the relationships of biofilm and saliva to dental caries and the significance of the balance between demineralization and remineralization for the development of carious lesions are discussed. Subsequent chapters address the state of the art in diagnosis and treatment, the implications of disease burden for prevention and the association between systemic diseases and dental caries. Dental Caries: Principles and Management is intended for dental school students, practicing dentists and researchers in dentistry.

Download Antimicrobial Peptides PDF
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Publisher : CABI
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ISBN 10 : 9781786390394
Pages : 286 pages
Rating : 4.7/5 (863 users)
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Download or read book Antimicrobial Peptides written by Guangshun Wang and published by CABI. This book was released on 2017-09-01 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide. Harnessing and creating AMPs synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. This new edition lays the foundations for studying AMPs, including a discovery timeline, terminology, nomenclature and classifications. It covers current advances in AMP research and examines state-of-the-art technologies such as bioinformatics, combinatorial libraries, high-throughput screening, database-guided identification, genomics and proteomics-based prediction, and structure-based design of AMPs. Thoroughly updated and revised, this second edition contains new content covering: defensins; cathelicidins; anti-MRSA, antifungal, antiviral, anticancer and antibiofilm strategies; combined treatments; adjuvants in vaccines; advances in AMP technologies that cover surface coating to prevent biofilm formation; nanofiber encapsulation technologies for delivery and sustained release; and understanding innate immunity and the basis for immune boosting to overcome obstacles in developing AMPs into therapeutic agents. Written and reviewed by a group of established investigators in the field, Antimicrobial Peptides is a valuable resource for postgraduate students, researchers, educators, and medical and industrial personnel.

Download Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential PDF
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Publisher : MDPI
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ISBN 10 : 9783038424628
Pages : 291 pages
Rating : 4.0/5 (384 users)
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Download or read book Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential written by Guangshun Wang and published by MDPI. This book was released on 2018-07-04 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential" that was published in Pharmaceuticals

Download Facing the Upcoming of Multidrug Resistant and Extensively Drug Resistant Bacteria  Novel Antimicrobial Therapies  NATs  PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889666539
Pages : 136 pages
Rating : 4.8/5 (896 users)
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Download or read book Facing the Upcoming of Multidrug Resistant and Extensively Drug Resistant Bacteria Novel Antimicrobial Therapies NATs written by Angel León-Buitimea and published by Frontiers Media SA. This book was released on 2021-04-01 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download New edge of antibiotic development  antimicrobial peptides and corresponding resistance PDF
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Publisher : Frontiers E-books
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ISBN 10 : 9782889193011
Pages : 145 pages
Rating : 4.8/5 (891 users)
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Download or read book New edge of antibiotic development antimicrobial peptides and corresponding resistance written by Octavio L. Franco and published by Frontiers E-books. This book was released on 2014-09-26 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects.

Download Antibiotic Drug Resistance PDF
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Publisher : John Wiley & Sons
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ISBN 10 : 9781119282525
Pages : 730 pages
Rating : 4.1/5 (192 users)
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Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Download Antimicrobial and Anticancer Peptides PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889454709
Pages : 137 pages
Rating : 4.8/5 (894 users)
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Download or read book Antimicrobial and Anticancer Peptides written by Neil M. O’Brien-Simpson and published by Frontiers Media SA. This book was released on 2018-05-03 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2014, the World Health Organization (WHO) listed cancer as the second leading cause of death and highlighted antimicrobial resistance as “a key global health challenge” that may, in a worst case scenario, lead to an annual death toll of 10 million by 2050, which would exceed predicted cancer deaths by 20%. Novel promising therapeutic options to reduce morbidity and mortality of both infectious microbial diseases and cancer are being developed based on antimicrobial peptides (AMPs), i.e., evolutionary proven antibiotics that also possess anti-cancer activities. Intriguingly, AMPs and anti-cancer peptides (ACPs) rely typically on novel mechanisms and cellular targets not used by current antibiotics or chemotherapeutics. Initiated by presentations at the International Meeting of Antimicrobial Peptides in 2016 (IMAP 2016), hosted at Leipzig University, Germany, this book compiles the most recent strategies and promising lead compounds for treating multi- and pan-resistant microbes and chemo-resistant cancer cells in fourteen different chapters representing leading research groups from five different continents. In this respect, the book shall stimulate new avenues of thinking and strategies in tackling forthcoming antimicrobial and cancer resistance health threats with the hope that the scenarios recently reported by the WHO will never eventuate.

Download Antimicrobial Peptides and Complement     Maximising the Inflammatory Response PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889197378
Pages : 159 pages
Rating : 4.8/5 (891 users)
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Download or read book Antimicrobial Peptides and Complement Maximising the Inflammatory Response written by Cordula M. Stover and published by Frontiers Media SA. This book was released on 2015-12-18 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response.

Download Head  Neck  and Orofacial Infections PDF
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Publisher : Elsevier Health Sciences
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ISBN 10 : 9780323289450
Pages : 497 pages
Rating : 4.3/5 (232 users)
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Download or read book Head Neck and Orofacial Infections written by James R. Hupp and published by Elsevier Health Sciences. This book was released on 2015-11-02 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use best practices in effectively treating infections of the head, neck, and orofacial complex! Head, Neck, and Orofacial Infections: An Interdisciplinary Approach is the only resource on the market with in-depth guidelines to the diagnosis and management of pathology due to severe infections. No longer do you have to search through journal articles and websites, as this comprehensive, full-color reference covers both cutting-edge and time-tested approaches to recognizing and handling infections. From well-known OMS educator James Hupp and oral surgeon Elie Ferneini, and with chapters written by expert contributors, this book is ideal for use in the classroom, as preparation for the NBDE and specialty exams, and as a clinical resource for patient care. UNIQUE! Comprehensive coverage of head, neck, and orofacial infections addresses the diagnosis and management of pathology due to infections of the head and neck and orofacial complex. Expert contributors are drawn from the disciplines of oral and maxillofacial surgery, head and neck surgery, plastic surgery, and otolaryngology, and they provide state-of-the-art guidance based on extensive experience with current techniques as well as technological advances in managing head, neck, and orofacial infections. Over 500 photographs, radiographs, and illustrations demonstrate pathologies, procedures, and outcomes. A logical organization addresses these topics: 1) issues that are common to all infections of the head and neck region, 2) infections of specific parts of the region, and 3) infections related to certain procedures, types of patients, unusual organisms, and medical-legal implications. Key chapters include: Odontogenic Infections of the Fascial Spaces chapter focuses on the etiology, clinical manifestations, anatomic considerations, and treatment of odontogenic infections. Nasal and Para-Nasal Sinus Infections chapter discusses the pathophysiology and management of nasal and paranasal sinus infections. Microbiologic Considerations with Dental Implants chapter reviews the issues associated with the prevention of infection with surgical implant placement, including the factors that are known to cause infection, the putative bacteria involved and means to control infection once it occurs.

Download The Challenging of Antibiotic Resistance in the Development of New Therapeutics PDF
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Publisher : Bentham Science Publishers
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ISBN 10 : 9781681081403
Pages : 279 pages
Rating : 4.6/5 (81 users)
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Download or read book The Challenging of Antibiotic Resistance in the Development of New Therapeutics written by Manuela Oliveira and published by Bentham Science Publishers. This book was released on 2015-12-03 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: The addition of only two novel classes of antibiotics to fight drug resistant microorganisms in the clinic over the past three decades means that the quest for new molecules that are effective against the threat of drug resistance is now a significant issue in modern medicine. Researchers have begun to experiment on alternative therapies to combat this threat. Novel chemical agents are considered to be drugs of choice for tomorrow's clinical practice owing to their low probability to generate resistance. The first volume of Frontiers in Antimicrobial Agents describes innovative alternatives to the classical antimicrobial therapeutics, such as phage therapy, AMPs, probiotics, novel biocides, natural products and immunotherapy. Cutting-edge research is brought to the forefront, shedding light on the developments taking place to meet the challenge of drug resistant microorganisms. The volume also features information on antimicrobial approaches in veterinary medicine. The book is a useful reference for researchers, microbiologists and healthcare professionals interested in updates on antibiotic resistance and alternatives to classical antibiotic therapy.

Download Surveying Antimicrobial Resistance  Approaches  Issues  and Challenges to Overcome PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782889451418
Pages : 421 pages
Rating : 4.8/5 (894 users)
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Download or read book Surveying Antimicrobial Resistance Approaches Issues and Challenges to Overcome written by Gilberto Igrejas and published by Frontiers Media SA. This book was released on 2017-03-29 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017

Download Editors    Showcase  Chemical Biology PDF
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Publisher : Frontiers Media SA
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ISBN 10 : 9782832500644
Pages : 175 pages
Rating : 4.8/5 (325 users)
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Download or read book Editors Showcase Chemical Biology written by John D. Wade and published by Frontiers Media SA. This book was released on 2022-09-23 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: