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Download Targeted Molecular Imaging in Oncology PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9781475735055
Pages : 290 pages
Rating : 4.4/5 (757 users)
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Download or read book Targeted Molecular Imaging in Oncology written by E. Edmund Kim and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Download Targeted Molecular Imaging PDF
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Publisher : Taylor & Francis
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ISBN 10 : 9781439841969
Pages : 388 pages
Rating : 4.4/5 (398 users)
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Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by Taylor & Francis. This book was released on 2012-02-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Download Targeted Molecular Imaging PDF
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Publisher : Springer
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ISBN 10 : 1489988335
Pages : 350 pages
Rating : 4.9/5 (883 users)
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Download or read book Targeted Molecular Imaging written by E. Edmund Kim and published by Springer. This book was released on 2010-10-16 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging: Principles and Applications presents the basic science behind personalized cancer medicine and accelerating drug approval from bench to clinic through the application of molecular imaging science and technology. Topics to be covered include the application of gamma scintigraphy (PET and SPECT) in oncology, the effect of contrast agents in PET/CT, radiation dosimetric determination for radiotheranostic agents, imaging technology in drug development, validation of imaging agents on new molecular targets, and economic potential for the development of molecular targeting agents and the process and requirements for FDA compliance.

Download Nuclear Medicine in Oncology PDF
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Publisher : Springer
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ISBN 10 : 9789811374586
Pages : 346 pages
Rating : 4.8/5 (113 users)
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Download or read book Nuclear Medicine in Oncology written by Gang Huang and published by Springer. This book was released on 2019-06-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the clinical application of the conventional imaging agent 18F-FDG in different tumors and neurodegenerative diseases and 18F-Dopa imaging in the nervous system are discussed. Besides the clinical applications of 99mTc labeled radiopharmaceuticals in parathyroid disease, coronary heart disease, myocardial infarction, sentinel lymph node, metastatic bone tumors, liver and gallbladder disease in children are introduced. Finally, the applications of radionuclide 131I on treatments of Graves' disease and differentiated thyroid cancer and metastases are investigated respectively. This book is a useful reference for professionals engaged in nuclear medicine and clinical research, including clinical nuclear medicine physicians, nuclear medicine engineers and nuclear medicine pharmacists.

Download Targeted Molecular Imaging PDF
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Publisher : CRC Press
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ISBN 10 : 9781439841952
Pages : 388 pages
Rating : 4.4/5 (398 users)
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Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by CRC Press. This book was released on 2012-02-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Download Synthesis and Application of Targeted Molecular Imaging Agents for Enhanced Disease Imaging and Therapy PDF
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Publisher :
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ISBN 10 : OCLC:298983422
Pages : 162 pages
Rating : 4.:/5 (298 users)
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Download or read book Synthesis and Application of Targeted Molecular Imaging Agents for Enhanced Disease Imaging and Therapy written by Mingfeng Bai and published by . This book was released on 2007 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Emerging Applications of Molecular Imaging to Oncology PDF
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Publisher : Elsevier
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ISBN 10 : 9780124116344
Pages : 402 pages
Rating : 4.1/5 (241 users)
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Download or read book Emerging Applications of Molecular Imaging to Oncology written by and published by Elsevier. This book was released on 2014-09-27 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume, number 124, covers emerging applications of molecular imaging to oncology, including molecular-genetic imaging, imaging the tumor microenvironment, tracking cells and vaccines in vivo, and more. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students

Download Modular Synthesis of Targeted Molecular Imaging Agents for MRI  PET  and PET MRI of Cancer PDF
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Publisher :
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ISBN 10 : OCLC:1143740239
Pages : 100 pages
Rating : 4.:/5 (114 users)
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Download or read book Modular Synthesis of Targeted Molecular Imaging Agents for MRI PET and PET MRI of Cancer written by Kelsea Jones and published by . This book was released on 2019 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Molecular imaging is a field widely used in the diagnosis and treatment of cancer. We offer here a modular method for the synthesis of targeted molecular imaging agents (TMIAs), which will improve the accuracy of current molecular imaging methods, as well as allow for earlier detection of tumors. The use of TMIAs in molecular imaging yields increased signal at cancerous cells and reduced signal from healthy cells. Our modular approach is useful as a facile method for the synthesis of dual-modal TMIAs for PET-MRI, which combine the sensitive detection of functional activity from PET with the high-resolution structural information obtained by MRI. Here, we present the synthesis of both a TMIA for the MRI of prostate cancer, followed by the synthesis of a dual-modal TMIA for use in simultaneous MRI-PET. By our method, a lysine backbone is utilized for the synthesis of imaging modules, by means of coupling the DOTA cyclene to the side chain of the lysine. A metal such as Gd3+ for use as an MRI contrast agent is chelated by DOTA. The imaging module is then coupled to a targeting moiety, such as c(RGDyK), through a carbon linker such as DSS or SMCC, to yield a novel TMIA. This same method is applied to the synthesis of dual-modal TMIAs featuring imaging modules for use in both MRI and PET. In the case of PET, where a radioactive isotope is required, we utilize a stable lanthanide placeholder that can be replaced by a useful metal isotope, such as 64Cu, at the end of the synthesis. Through the course of this research, our modular approach to the synthesis of TMIAs has proven to be an effective method of synthesis, and intermediate steps have been optimized. Additionally, methods of measuring the relaxivity of MRI contrast agents have been applied to our novel compounds for comparison with commercial agents available in clinical labs, hospitals, and imaging centers today."--Abstract.

Download Molecular Imaging  Basic Principles And Applications In Biomedical Research  2nd Edition  PDF
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Publisher : World Scientific
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ISBN 10 : 9781783263172
Pages : 620 pages
Rating : 4.7/5 (832 users)
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Download or read book Molecular Imaging Basic Principles And Applications In Biomedical Research 2nd Edition written by Rudin Markus and published by World Scientific. This book was released on 2013-07-04 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies.The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.

Download Molecular Imaging  Basic Principles And Applications In Biomedical Research  3rd Edition  PDF
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Publisher : World Scientific
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ISBN 10 : 9781786346865
Pages : 800 pages
Rating : 4.7/5 (863 users)
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Download or read book Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition written by Markus Rudin and published by World Scientific. This book was released on 2020-04-04 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.

Download Solid Phase Synthesis of Modular Peptide based Targeted Molecular Imaging Agents PDF
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Publisher :
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ISBN 10 : OCLC:1153359516
Pages : 83 pages
Rating : 4.:/5 (115 users)
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Download or read book Solid Phase Synthesis of Modular Peptide based Targeted Molecular Imaging Agents written by Xinyu Xu and published by . This book was released on 2019 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Targeted molecular imaging agents (TMIA) are emerging as useful tools for early diagnosis of cancer and other diseases. These agents couple imaging agents such as near infrared fluorescence (NIRF) dyes or metallic contrast agents such as gadolinium (Gd) used in magnetic resonance imaging (MRI) to targeting agents that bind to biomarker receptors in cancer cells. Our group has developed a modular synthesis of peptide-based TMIAs containing these two agents starting from “puzzle pieces”. Puzzle pieces, or modules, are amino acids with imaging groups bonded to their side chains. These are assembled together to form imaging peptides which are then conjugated to targeting groups. The research goal was to synthesize targeting peptides using solid phase peptide synthesis (SPPS), and then add the imaging puzzle pieces to these in the same SPPS method. SPPS is widely used and has many advantages in the synthesis of TMIAs. The first goal, to learn how to synthesize simple peptides by SPPS, was accomplished. The second goal of making Met-enkephalin, a bioactive penta-peptide, and conjugating the imaging puzzle pieces containing a NIRF dye or gadolinium chelate for MRI by SPPS was also successful. The final goal, to synthesize a deca-peptide, 18-4a, useful for targeting breast cancer and then to couple these same imaging puzzle pieces, to the peptide 18-4 in the last step, was also accomplished."--Abstract.

Download Aptamers PDF
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Publisher : CRC Press
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ISBN 10 : 9789814669849
Pages : 386 pages
Rating : 4.8/5 (146 users)
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Download or read book Aptamers written by Rakesh N. Veedu and published by CRC Press. This book was released on 2017-03-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aptamers, often termed as ‘chemical antibodies,’ are an emerging class of synthetic ligands for efficient target-specific molecular recognition. The objective of this book is to highlight recent advances and potential of aptamers in various disease conditions. . This book focuses on the applications of aptamers in targeted nanotherapy, detection, and in molecular imaging in various disease conditions such as cancer, neurological diseases and infectious diseases.

Download Targeted Therapy  Molecular Imaging and Biomarkers in Cancer Treatment PDF
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Publisher :
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ISBN 10 : 9462598053
Pages : pages
Rating : 4.5/5 (98 users)
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Download or read book Targeted Therapy Molecular Imaging and Biomarkers in Cancer Treatment written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Modular Synthesis of Dual  and Tri modal Targeted Molecular Imaging Agents PDF
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Publisher :
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ISBN 10 : OCLC:1156986671
Pages : 105 pages
Rating : 4.:/5 (115 users)
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Download or read book Modular Synthesis of Dual and Tri modal Targeted Molecular Imaging Agents written by Nicholas C. Schug and published by . This book was released on 2020 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: "There are few reported methods for combining two or three different imaging dyes, metals, or dye-metal combinations, followed by the conjugation of a disease- targeting group to enable the use a given imaging system for multiple imaging applications. Previously, peptides have been used as scaffolds for dyes and metals used in diagnostic techniques such as optical molecular imaging (OMI), positron emission tomography (PET), and magnetic resonance imaging (MRI). The aim of this project was to reassemble peptide-based imaging agents through a modular method by coupling together modules comprised of amino acids with imaging agents attached to their side chains to form “imaging peptides,” followed by attaching a cancer-targeting group in the final step. This new modular approach for the synthesis of a diverse set of targeted molecular imaging agents (TMIAs) was optimized and exemplified by the synthesis of dual modal PET-MRI, dual OMI-MRI and dual metal (di-gadolinium for MRI), and the partial synthesis of a tri-modal OMI-PET-MRI agent. The dual modal imaging peptides were conjugated through a linker to targeting groups for lung cancer (A549 cells) and prostate cancer (PSMA positive C4-2) cells. In addition to imaging applications for early detection, active surveillance, image guided biopsies and surgery, this modular approach could potentially be used for creating therapeutic agents to treat cancer patients."--Abstract.

Download Synthesis of Single modal and Dual modal Targeted Molecular Imaging Agents for MRI NIR Imaging of Breast Cancer PDF
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ISBN 10 : OCLC:1265302100
Pages : 123 pages
Rating : 4.:/5 (126 users)
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Download or read book Synthesis of Single modal and Dual modal Targeted Molecular Imaging Agents for MRI NIR Imaging of Breast Cancer written by Basant Kaur and published by . This book was released on 2021 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Our research is focused on the early and accurate detection of breast cancer (BrCa) by molecular imaging. Breast cancer is the most common type of cancer among women. Each year about one in eight women will be diagnosed, and over 500,000 deaths occur from breast cancer globally. To improve chances of survival, breast cancer must be diagnosed and treated at an early stage. Conventional imaging uses mammography, magnetic resonance imaging (MRI), and ultrasound. Limitations in these can result in false-positive results or undetected tumors. It is vital to create more sensitive imaging methods to diagnose BrCa, to reduce false-positives and to guide therapy. A new approach to targeted molecular imaging agents (TMIAs) for BrCa will be described for single-modal and dual-modal imaging by fluorescence and MRI. To target these imaging agents, we employed a new BrCa-targeting peptide called 18-4. This peptide was synthesized by solid phase peptide synthesis (SPPS) followed by conjugation of a near infrared dye, Cy5.5-1S, utilizing a new modular method developed in our lab, to form M3, an imaging agent for BrCa. The modular method was then utilized to construct a single-modal agent containing the MRI-contrast agent metal gadolinium. Lastly, a dual modal targeted imaging agent containing both Gd and Cy5.5-1S for dual modal fluorescence-MRI of BrCa was synthesized. This is the first example of a dual-modal TMIA that is synthesized entirely by SPPS, where the imaging agents are brought in on the side chain of amino acids that coupled as part of the solid phase synthetic approach."--Abstract.

Download From Morphological Imaging to Molecular Targeting PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 3540201378
Pages : 196 pages
Rating : 4.2/5 (13 users)
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Download or read book From Morphological Imaging to Molecular Targeting written by Markus Schwaiger and published by Springer Science & Business Media. This book was released on 2004-06-16 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current progress in molecular medicine allows the identification of a plethora of new and often human-specific drug targets. An early in vivo validation of specific ligands binding to these targets in humans is needed to assess their potential for targeted imaging and radiotherapy. Radiopharmaceuticals are uniquely suitable for such target validation studies. The purpose of the Ernst Schering Research Foundation Workshop 48 was to offer a forum for an open exchange on the state of the art in the early development of such radiopharmaceuticals. Experts from academia, industry and regulatory authorities provided contributions covering the identification of targets, the necessary preclinical studies on the safety of ligands as well as their validation in human clinical trials.