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Download Targeted Molecular Imaging in Oncology PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 0387950281
Pages : 322 pages
Rating : 4.9/5 (52 users)
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Download or read book Targeted Molecular Imaging in Oncology written by E. Edmund Kim and published by Springer Science & Business Media. This book was released on 2001 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cells dedifferentiate with repect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also describes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Download Targeted Molecular Imaging PDF
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Publisher : Taylor & Francis
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ISBN 10 : 9781439841969
Pages : 388 pages
Rating : 4.4/5 (398 users)
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Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by Taylor & Francis. This book was released on 2012-02-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Download Targeted Molecular Imaging PDF
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Publisher : CRC Press
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ISBN 10 : 9781439841952
Pages : 390 pages
Rating : 4.4/5 (398 users)
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Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by CRC Press. This book was released on 2012-02-24 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Download Nuclear Medicine in Oncology PDF
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Publisher : Springer
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ISBN 10 : 9789811374586
Pages : 346 pages
Rating : 4.8/5 (113 users)
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Download or read book Nuclear Medicine in Oncology written by Gang Huang and published by Springer. This book was released on 2019-06-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the clinical application of the conventional imaging agent 18F-FDG in different tumors and neurodegenerative diseases and 18F-Dopa imaging in the nervous system are discussed. Besides the clinical applications of 99mTc labeled radiopharmaceuticals in parathyroid disease, coronary heart disease, myocardial infarction, sentinel lymph node, metastatic bone tumors, liver and gallbladder disease in children are introduced. Finally, the applications of radionuclide 131I on treatments of Graves' disease and differentiated thyroid cancer and metastases are investigated respectively. This book is a useful reference for professionals engaged in nuclear medicine and clinical research, including clinical nuclear medicine physicians, nuclear medicine engineers and nuclear medicine pharmacists.

Download Molecular Imaging Approaches for Targeting Tumors and Immune System tumor Cells Interaction PDF
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ISBN 10 : OCLC:1104912287
Pages : pages
Rating : 4.:/5 (11 users)
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Download or read book Molecular Imaging Approaches for Targeting Tumors and Immune System tumor Cells Interaction written by Calogero D'Alessandria and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download Molecular Imaging PDF
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Publisher : PMPH-USA
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ISBN 10 : 1607950057
Pages : 1384 pages
Rating : 4.9/5 (5 users)
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Download or read book Molecular Imaging written by Ralph Weissleder and published by PMPH-USA. This book was released on 2010 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.

Download Molecular Imaging PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 3540210210
Pages : 278 pages
Rating : 4.2/5 (12 users)
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Download or read book Molecular Imaging written by Alexei Bogdanov and published by Springer Science & Business Media. This book was released on 2004-10-07 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

Download The Chemistry of Molecular Imaging PDF
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Publisher : John Wiley & Sons
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ISBN 10 : 9781118093276
Pages : 431 pages
Rating : 4.1/5 (18 users)
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Download or read book The Chemistry of Molecular Imaging written by Nicholas Long and published by John Wiley & Sons. This book was released on 2014-12-31 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular imaging is primarily about the chemistry of novel biological probes, yet the vast majority of practitioners are not chemists or biochemists. This is the first book, written from a chemist's point of view, to address the nature of the chemical interaction between probe and environment to help elucidate biochemical detail instead of bulk anatomy. Covers all of the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry Focuses primarily on the chemistry of probes and imaging agents, and chemical methodology for labelling and bioconjugation First book to investigate the chemistry of molecular imaging Aimed at students as well as researchers involved in the area of molecular imaging

Download Molecular Imaging and Precision Medicine  Part II  An Issue of PET Clinics  E Book PDF
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Publisher : Elsevier Health Sciences
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ISBN 10 : 9780323546812
Pages : pages
Rating : 4.3/5 (235 users)
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Download or read book Molecular Imaging and Precision Medicine Part II An Issue of PET Clinics E Book written by Rathan Subramaniam and published by Elsevier Health Sciences. This book was released on 2017-09-14 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of PET Clinics focuses on Molecular Imaging and Precision Medicine, Part II, and is edited by Dr. Rathan Subramaniam. Articles will include: Precision Medicine in Esophageal Cancer; Precision Medicine and PET/CT in Melanoma; Precision Medicine and PET/CT in Hepatobilliary and Pancreatic Cancer; Precision Medicine and PET/CT in Gastric Cancer; Precision Medicine and PET/CT in Skeletal and Soft Tissue Sarcomas; Precision Medicine and PET/MRI; Precision Medicine and PET/CT in Uterine and Ovarian Cancers; Precision Medicine and PET/CT in Cardiovascular Disorders, and more!

Download New Probe for Molecular Imaging PDF
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Publisher : LAP Lambert Academic Publishing
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ISBN 10 : 3659416207
Pages : 132 pages
Rating : 4.4/5 (162 users)
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Download or read book New Probe for Molecular Imaging written by Enrico Chiavazza and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowadays, imaging techniques are an indispensable tool in cancer research, clinical trials and medical practice and they are of great aid for oncologists to localize and characterize abnormal tissues. Detection and characterization of lesions, especially tumors, can be achieved by using specific tracers or contrast media that are capable of selectively interact with the biological target. This approach is defined as Molecular Imaging. A MI probe is usually composed of a biologically active component (vector) that interacts with the intended molecular target, an imaging reporter that should produce a detectable signal and a linker between the two components. Among the different imaging modalities only a few are characterized by the merging of these functional units into one molecular identity: PET tracers and Hyperpolarized MRI probes use labeled nuclides (either radioactive or stable) as imaging reporters within the biologically active molecule. My work has dealt with the development of hyperpolarized MRI tracers, which are able to overcome the sensitivity issue typical of the MRI methodology avoiding the radiological concerns that negatively affect the use of nuclear techniques.

Download From Morphological Imaging to Molecular Targeting PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 3540201378
Pages : 218 pages
Rating : 4.2/5 (13 users)
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Download or read book From Morphological Imaging to Molecular Targeting written by Markus Schwaiger and published by Springer Science & Business Media. This book was released on 2004-06-16 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current progress in molecular medicine allows the identification of a plethora of new and often human-specific drug targets. An early in vivo validation of specific ligands binding to these targets in humans is needed to assess their potential for targeted imaging and radiotherapy. Radiopharmaceuticals are uniquely suitable for such target validation studies. The purpose of the Ernst Schering Research Foundation Workshop 48 was to offer a forum for an open exchange on the state of the art in the early development of such radiopharmaceuticals. Experts from academia, industry and regulatory authorities provided contributions covering the identification of targets, the necessary preclinical studies on the safety of ligands as well as their validation in human clinical trials.

Download Molecular Imaging PDF
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ISBN 10 : 184816856X
Pages : 593 pages
Rating : 4.1/5 (685 users)
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Download or read book Molecular Imaging written by Markus Rudin and published by . This book was released on 2013 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today. This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies. The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.

Download Molecular Imaging in Oncology PDF
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Publisher : Springer Science & Business Media
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ISBN 10 : 9783642108532
Pages : 416 pages
Rating : 4.6/5 (421 users)
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Download or read book Molecular Imaging in Oncology written by Otmar Schober and published by Springer Science & Business Media. This book was released on 2012-11-28 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.

Download Targeted Cancer Imaging PDF
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Publisher : Academic Press
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ISBN 10 : 9780128245149
Pages : 216 pages
Rating : 4.1/5 (282 users)
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Download or read book Targeted Cancer Imaging written by Mehdi Azizi and published by Academic Press. This book was released on 2021-12-10 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes Shows how to design, synthesize and apply cancer imaging nanostructures

Download Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes PDF
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Publisher : Academic Press
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ISBN 10 : 9780128097182
Pages : 552 pages
Rating : 4.1/5 (28 users)
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Download or read book Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes written by Vijay Mishra and published by Academic Press. This book was released on 2017-05-23 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Download Biomaterials for Cancer Therapeutics PDF
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Publisher : Woodhead Publishing
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ISBN 10 : 9780081029848
Pages : 782 pages
Rating : 4.0/5 (81 users)
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Download or read book Biomaterials for Cancer Therapeutics written by Kinam Park and published by Woodhead Publishing. This book was released on 2020-03-05 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion. Provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment and prevention of cancer Discusses how the properties of specific biomaterials make them important in cancer treatment Covers synthetic vaccines, proteins and polymers for cancer therapeutics

Download Evaluation of the Neurotensin Receptor 1 as Target for Molecular Imaging and Radiotherapy of Pancreatic and Prostate Cancer PDF
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ISBN 10 : OCLC:1057667255
Pages : pages
Rating : 4.:/5 (15 users)
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Download or read book Evaluation of the Neurotensin Receptor 1 as Target for Molecular Imaging and Radiotherapy of Pancreatic and Prostate Cancer written by Sandra Geer and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: